[, Bae YJ, Kim MH. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. Limits foods and beverages higher in added sugars, saturated fat, and sodium. Rare genetic mutations in the manganese transporter can cause severe developmental delay, short stature, seizures, and other symptoms. Dietary supplements Turmeric has been used in Ayurvedic medicine to treat various conditions. You may also notice brown spots on the leaves if the problem persists for an extended period. The levels for children vary, depending on age. A person that does have a deficiency in manganese could experience the following symptoms: poor bone growth or skeletal defects slow or impaired growth low fertility impaired glucose tolerance,. We get most of our manganese through diet. Baltimore, MD: Lippincott Williams & Wilkins; 2014:238-44. However, it can definitely go bad. eCollection 2015. Dietary manganese intake and type of lipid do not affect clinical or neuropsychological measures in healthy young women. Therefore, manganese deficiency in these diseases is not considered a health concern, but it may be worth asking your doctor about your manganese levels occasionally if youre worried. Several studies have investigated the effects of low (but not deficient) manganese. We encourage you to talk to your health care providers (doctor, registered dietitian, pharmacist, etc.) Brain manganese and the balance between essential roles and neurotoxicity. Manganese combines with other elements to form an essential antioxidant enzyme in your body (think of the Megazord from Power Rangers but inside you). Manganese deficiency due to diet is extremely rare and has never been reported in humans. They can help estimate recent exposure to manganese, spanning a couple of months before the test [13, 14]. Theres actually more concern about manganese toxicity than deficiency its important not to consume too much. This study included 1,614 adults with type 2 diabetes (mean age 52.5 years) and 1,614 adults without diabetes (mean age 54.7 years). (2020). According to the Linus Pauling Institute, the adequate daily intake for manganese is 2.3 milligrams per day in adult men and 1.8 milligrams per day in adult women. Minerals help your body carry out essential processes. These included a lack of coordination and stability. All of our content is written by scientists and people with a strong science background. Essential Trace Metal (Zinc, Manganese, Copper and Iron) Levels in Plants of Medicinal Importance. Includes a variety of protein foods such as lean meats; poultry; eggs; seafood; beans, peas, and lentils; nuts and seeds; and soy products. Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China. Disclaimer, National Library of Medicine Role for calcium signaling in manganese neurotoxicity. Follow this recipe for a Mediterranean brown rice salad. This site needs JavaScript to work properly. Nutritional yeast is a culinary chameleon. AI is the estimated amount of the nutrient that is used by a group of healthy people and assumed to be adequate. . Join the ODS Email List. That was until 2015, when a rare genetic mutation in a manganese uptake transporter gene (SLC39A8) was discovered [20, 21]. For a quick, healthy, manganese-loaded snack, open a can of chickpeas, drain them well, and spread them on a sheet pan. Joe is a thriving entrepreneur, with a mission to empower people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time. You can get all the manganese you need through your diet. People who have a diet that is rich in these minerals or those who are on mineral supplements need to take suitable precautions to ensure that they meet their requirement for manganese. People eating vegetarian diets and Western-type diets may have manganese intakes as high as 10.9 mg/day, which is close to the upper safe limit from all sources [52]. 10 Best Multivitamins for Women Over 50 in 2023, According to Dietitians, 12 Best Postnatal Vitamins for 2023, According to a Dietitian, Tips and Picks for Vitamin Deficiency Tests You Can Order Online, The 14 Best Fish Oil Supplements of 2023, According to Dietitians, impaired glucose tolerance, a state between normal glucose maintenance and diabetes, abnormal metabolism of carbohydrate and fat, exocrine pancreatic insufficiency (an inability to digest food due to a deficiency of digestive enzymes produced by the pancreas), beans and legumes, such as lima and pinto beans. If you dont get enough, you could end up with manganese deficiency and you might not know it. Manganese homeostasis in the nervous system. Pennington JA, Young BE. Correlation between bone mineral density and serum trace element contents of elderly males in Beijing urban area. The effects of manganese deficiency have not been well studied in humans. Compared with the middle tertile of plasma manganese concentration (4.216.84 mcg/L), those in the lowest tertile (4.21 mcg/L) were 1.89 times more likely, and those in the highest tertile (6.84 mcg/L) were 1.56 times more likely, to have type 2 diabetes. According to this publication, dietary manganese intakes were 1.1 mg/day for infants aged 6 to 11 months, 1.48 mg/day for children aged 2 years, 1.78 to 2.76 mg/day for boys and girls aged 14 to 16 years, 2.14 to 2.23 mg/day for women, and 2.64 to 2.81 mg/day for men [21]. It is required for the normal development, growth, and function of our bodies [1, 2, 3]. Although these conditions are not considered to be manganese deficiency diseases, a supplement that contains manganese along with other minerals can improve bone density and overall bone health. In other words, not all people suffering from these diseases have low manganese levels. The highest levels of manganese can be found in [48, 7, 2, 31]: The adult dietary intake of manganese is normally anywhere from 0.9 to 10 mg per day, while the US National Research Council has established an estimated safe and adequate dietary intake of 25 mg/day for adults [50, 5, 31, 51]. Lonnerdal B. Nutritional aspects of soy formula. Manganese deficiency often appears as patches of pale, floppy wheat in an otherwise green healthy crop. It can also make PMS symptoms worse. Epub 2019 Aug 22. If you have a manganese deficiency, your doctor will likely prescribe manganese supplementation. So make sure you research reliable supplements that contain the ingredients they claim to. One of the simplest ways to increase your intake of manganese is to have a cup of black tea with your breakfast as this will provide 24 percent of your daily requirement for this mineral. Buchman AR. Most people get enough manganese from the food they eat. Manganese, Molybdenum, Boron, Chromium, and Other Trace Elements. You dont need a special recipe to get a manganese boost. All rights reserved. Bethesda, MD 20894, Web Policies Ginger is also a good source of manganese as 1 tablespoon of ground ginger will provide 70 percent of your daily manganese requirement. You can find that study here. Once you consume it, your body stores manganese in organs like your liver, kidney, and pancreas, as well as in your bone tissue. In order to perform the test, your doctor will need to obtain a blood sample from a vein in your arm. Online ahead of print. The objective of this chapter is to address the biological importance of Mn (essentiality), routes of exposure, factors dictating Mn status, a brief discussion of Mn neurotoxicity, and proposed methods for neurotoxicity remediation. GUILARTE R. T. Manganese and Parkinson's disease: a critical review . Front Biosci (Landmark Ed) 2018;23:1655-79. Manganese neurotoxicity: a focus on the neonate. We found some great-tasting, versatile recipes to help you get your manganese levels back on track. Taking unnecessary supplements can cause an overdose of manganese, which will lead to serious health issues. Last medically reviewed on March 12, 2018. 11th ed. Plus, some of the possible symptoms of manganese deficiency, like skin changes and mood changes, are vague and could very well have links to another health condition or nutrient deficiency. A person that does have a deficiency in manganese could experience the following symptoms: Manganese deficiency could be caused by not having enough manganese in your diet. An antioxidant stops harmful free radicals from damaging your cells. U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes. Medical Center. Manganese is taken up by the liver and other tissues, but the mechanism of this process is not well understood [1,2]. official website and that any information you provide is encrypted Normal manganese levels in the blood are 4-15 ug/L. If not amended, brown necrotic spots may appear on the leaf surface, and severely affected leaves turn brown and wither. More than 90% of absorbed manganese is excreted via bile into the feces, and a small amount is reabsorbed [1,2,4,5]. [. Our content does not constitute a medical consultation. (2018). Not all multivitamin/mineral supplements contain manganese, but those that do typically provide 1.0 to 4.5 mg manganese [18]. Manganese superoxide dismutase (MnSOD) is the principal antioxidant in mitochondria. J Am Diet Assoc 1991;91:179-83. It happens in areas that contain light textured soils, manganese deficiency, low organic matter content, and pH above 6.5. Its deficiency is most common in coarse-textured, low organic matter coastal plain soils where levels . However, manganese toxicity has occurred in people working in such occupations as welding and mining who were exposed to high amounts of manganese from chronic inhalation of manganese dust [1,39]. Information is shared for educational purposes only. Increasing manganese intake may help to alleviate the symptoms of premenstrual syndrome (PMS). Ijomone OM, Aluko OM, Okoh COA, Martins AC Jr, Aschner M. J Trace Elem Med Biol. These values met or exceeded the manganese AI for all age groups. 2015. Our goal is to not have a single piece of inaccurate information on this website. Manganese is an essential trace element that is naturally present in many foods and available as a dietary supplement. However, manganese deficiency in animals has been found to cause skeletal defects such as: Additionally, pregnant animals that were deficient in manganese gave birth to offspring that had significant movement issues. You can get a whole range of vitamins and minerals with extra flavors to boot. FOIA Manganese is found pretty much everywhere: in the air, water, and soil. Can magnesium play a key role in osteoporosis? Several enzymes activated by manganese contribute to the metabolism of carbohydrates, amino acids, and cholesterol. In one small clinical trial, supplementation with calcium (1,000 mg) plus trace minerals (5 mg manganese, 15 mg zinc, and 2.5 mg copper) for 2 years improved spinal bone density compared with placebo in 59 healthy postmenopausal women (mean age 66 years) [29]. Chen P, et al. In animals, low dietary manganese impairs growth, prevents proper bone formation and causes skeletal defects, decreases glucose tolerance, and impairs fat and carb metabolism [26, 27]. The National Health and Nutrition Examination Survey, which provides dietary intake data for most nutrients, does not include manganese [19]. Our website services, content, and products are for informational purposes only. However, people who have trouble getting rid of manganese from the body, such as people with liver disease, may . Data on manganese intakes from dietary supplements are not currently available. Add just a pinch or two of these spices to your cup of tea to increase its manganese content. Manganese is an essential nutrient necessary for many important bodily functions. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Manganese deficiency is very rare because most people get plenty in their diets. Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada) dedicated to using leading-edge science to save and improve lives around the world. This will affect the production of insulin and cause diabetes. 2022 Sep 9;11(18):2791. doi: 10.3390/foods11182791. 2015 Mar 24;6:45. doi: 10.4103/2152-7806.153876. However, it does rarely happen in people with certain gene mutations. Data on manganese intakes are very limited, but they suggest that most people obtain adequate amounts of manganese. The top sources of manganese in the diets of U.S. adults are grain products, tea, and vegetables [4]. Manganese homeostasis in the nervous system. [, Walter RM, Jr., Uriu-Hare JY, Olin KL, Oster MH, Anawalt BD, Critchfield JW, et al. 2007 Feb;113(2):369-77. doi: 10.1016/j.pharmthera.2006.09.002. DRI is the general term for a set of reference values used for planning and assessing nutrient intakes of healthy people. Inhaled manganese can cause inflammation of the lungs. Complete absence of manganese produces a mottling of the younger leaves and death of the growing tip as previously reported. Theyll also suggest that you try to include more manganese-rich foods in your diet. Consuming bad lemon juice can cause food poisoning and digestive distress. government site. Epub 2006 Sep 22. Collagen formation is essential to wound healing. Manganese is a powerful mineral that helps strengthen your brain and body. Deficiencies are rare but can happen. In addition, men appear to absorb dietary manganese less efficiently than women, possibly because men usually have higher iron status [7,16]. For example, in a case-control study in China of 122 adults with newly diagnosed type 2 diabetes and 429 adults without diabetes (age range for all participants was 4092 years), those in the highest tertile of plasma manganese (>2.42 mcg/L) were 7.88 times more likely to have diabetes than those in the lowest tertile (<1.67 mcg/L) [30]. Iron deficiency increases manganese absorption and can therefore exacerbate symptoms of manganese toxicity [2]. It is more likely to have manganese toxicity than it is to have a deficiency. Because of the role of manganese as a cofactor for several enzymes, low intakes might increase the risk of illness. [, Saltman PD, Strause LG. Medindia. Updated: Read on to find out more about manganese deficiency, the health effects of low manganese levels, and foods high in manganese that boost your levels safely. Kidney beans, canned, drained, rinsed, cup, Tuna, white, canned in water, drained, 3 ounces. Manganese deficiency has not been conclusively documented, although one experimental case in a volunteer resulted in transient dermatitis, hypocholesterolemia, and increased alkaline phosphatase levels. Mol Aspects Med 2005;26:353-62. According to users, manganese supplements caused a short-term boost in energy, but people often report side effects such as emotional instability, mood issues, racing pulse, nausea, and fatigue. Cranial cruciate ligament (CCL) disease in dogs arises all too frequently these days. PMC Manganese Deficiency - Causes, Symptoms, Functions, Food Sources and Supplements. Manganese is not known to have any clinically relevant interactions with medications. [. Sex hormone production and reproductive function [, 4-15 g/L in blood (that is equal to 72.8 273 nmol/L), 0.4-0.85 g/L in serum (the liquid component of blood), A movement disorder resembling tremors (dystonia), Perthes disease, a rare childhood condition [, Exocrine pancreatic insufficiency (lack of. Initially, middle leaves are affected first, but it can be difficult to determine which leaves are most affected as symptoms rapidly spread to other leaves and the growing point. Introduction. (See also Overview of Mineral Deficiency and Toxicity .) Blood metals concentration in type 1 and type 2 diabetics. Biomed Environ Sci 2017;30:482-91. (2019). According to Mayo Clinic Laboratories, the normal reference range for manganese in adults is between 4.7 and 18.3 nanograms per milliliter (ng/mL). And what happens when you dont? Bone health Potential symptoms of low manganese (not due to genetic reasons) include: Because of the rarity of manganese deficiency, these symptoms are more likely to be produced by another underlying condition. Multivitamins, for example, often include it. 2015;33(2):229-54. doi: 10.1080/10590501.2015.1030530. Environ Health Perspect 2016;124:1876-81. Which foods are the best sources of manganese? Therefore, scientists have examined whether manganese status affects the risk of diabetes. Kim G, Lee HS, Seok Bang J, Kim B, Ko D, Yang M. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. Learn why this test may be necessary and the signs and. Interestingly enough, many individuals with liver disease also suffer with magnesium deficiency, which has been correlated to the birthing of the disease. Intake of higher amounts of iron, calcium, and phosphorus (from food or supplements) may prevent manganese absorption [49]. Very low or very high manganese are linked with cognitive deficits and metabolic problems, so its important to keep manganese consumption in balance. Small necrotic lesions develop on the chlorotic areas. Use OR to account for alternate terms Get more legumes, nuts, and whole grains like brown rice or whole wheat bread [48, 7]. Manganese (Mn), necessary for healthy bone structure, is a component of several enzyme systems, including manganese -specific glycosyltransferases and phosphoenolpyruvate carboxykinase. Align your health hacks with your genes for optimal health & cognitive function. A supplement can be a quick way to increase your intake of omega-3 fatty acids. Since manganese is found in many foods within our daily diets, reports of manganese deficiency are rare. Li L, Yang X. The Total Diet Study (TDS) is an FDA program that monitors the nutrient content of typical foods consumed by the U.S population [20]. In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients (e.g., during specific life stages such as pregnancy).". U.S. Department of Agriculture, Agricultural Research Service. Its so rare in humans that the National Institutes of Health doesnt single out any specific groups of people who are more likely to have it than others. The most common cause of low manganese levels is a poor dietary intake. . [. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. By growing peas in water cultures with carefully regulated amounts of manganese, the effects of a deficiency of this element have been studied. Joe Cohen flipped the script on conventional and alternative medicine and it worked. 2022 Aug 18;12(16):2116. doi: 10.3390/ani12162116. Aendo P, De Garine-Wichatitsky M, Mingkhwan R, Senachai K, Santativongchai P, Krajanglikit P, Tulayakul P. Foods. All rights reserved. Which, yknow, absolutely no one needs. Manganese Deficiency - Causes, Symptoms, Functions, Food Sources and Supplements. RBC (red blood cell) manganese levels are a better measure of the actual content of manganese in tissues. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. [. Median intake is between 1.6 and 2.3 mg/day; absorption is 5 to 10%. Manganese is important for several functions in your body. Inhaled manganese toxicity is an occupational hazard for some workers. This is due to the fact that low levels of manganese affect the metabolism of glucose. Manganese and Lyme. More research is needed to determine whether manganese plays any role in the development of diabetes. Peres TV, et al. Epub 2006 Jun 21. For those worried about toxicity due to long-term, low-dose manganese, hair, nail, and bone manganese content may give a more accurate exposure estimate [15, 10]. Although we require only a small amount of this mineral, its absence can have serious health repercussions. Tolerable Upper Intake Level (UL): Maximum daily intake unlikely to cause adverse health effects. Federal government websites often end in .gov or .mil. The adult dietary intake of manganese is normally anywhere from 0.9 to 10 mg per day, while the US National Research Council has established an estimated safe and adequate dietary intake of 25 mg/day for adults [. Medindia. Its essential to talk with a medical professional before taking a supplement, since too much manganese can cause serious harm to your body. A current review for biological monitoring of manganese with exposure, susceptibility, and response biomarkers. Shaun DMello. But while it is a required part of a healthy diet, exposure to excess levels can be toxic [8]. . Many dietary supplements that contain manganese are listed in the Dietary Supplement Label Database from the National Institutes of Health [18]. Antioxidants are an important benefit of eating fruits and veggies. [, Finley JW. [, Odabasi E, Turan M, Aydin A, Akay C, Kutlu M. Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Chapter 10. We avoid using tertiary references. KOOLHAAS, J. M. 5-HT1A and 5-HT1B receptor agonists and aggression: A pharmacological challenge of the serotonin deficiency hypothesis. Indian J Med Res. bone formation probs and skeletal anomalies, create insulin, which helps regulate your blood sugar levels, give your metabolism a kick in the pants (letting you process. The federal government's 20202025 Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods. However, these concentrations often do not correlate well with typical manganese intakes, so whether they are useful indicators of manganese status is not clear [4]. Comment * document.getElementById("comment").setAttribute( "id", "a06bd7d785b822fb1f146d4250b15d66" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Women over the age of 50 have increased needs for several vitamins and minerals. Lee S-H, et al. Turmeric Dosage: How Much Should You Take Per Day? . Some examples of foods that are good sources of manganese include: Iron-rich foods or supplements have been shown to lower your absorption of manganese. Manganese absorption and retention by young women is associated with serum ferritin concentration. 504 p. . Studies have shown that for every 100mg increase in magnesium intake there is a 49% decrease in the risk of mortality due to all liver diseases. [. Manganese supplementation can be used to manage this condition. When using soil or hydroponics, keep it between 5.5 to 6.0. In one study, 10 women with osteoporosis (mean age, 69.3 years) had lower serum manganese levels (20 mcg/L) than 20 women (mean age, 64.5 years) who did not have osteoporosis (40 mcg/L) [25]. Manganese supplementation improves mineral density of the spine and femur and serum osteocalcin in rats. Around the web, manganese is discussed as a histamine-lowering and dopamine-increasing agent, although there is little research to support this. Manganese (chemical symbol Mn) deficiency occurs in a wide range of crops with onions, beetroot, parsnip, cabbage, cauliflower, tomato and pumpkin the most susceptible. Blood Trace Element Status in Camels: A Review. Acta Paediatr Suppl 1994;402:105-8. Manganese is essential for enzymes that help form bone and cartilage. However,. Zofkova I, Nemcikova P, Matucha P. Trace elements and bone health. Here's how to spot a spoiled or rancid jar of peanut butter. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs. Diet and Nutrition Notova SV, Lebedev SV, Marshinskaia OV, Kazakova TV, Ajsuvakova OP. If you do choose to supplement, talk to your doctor first and be wary of the toxic effects of high manganese levels. A 2013 study on mice suggests it could help with blood sugar control in diabetes. As a plant-rich diet provides more than enough manganese for most of us, you may want to skip manganese and opt for other supplements that can provide the same benefits but without the toxic effects. Most people already have more than an adequate intake of manganese and should be careful when supplementing this metal. Four cations: Sodium, potassium, calcium, and magnesium Two accompanying anions: Chloride and phosphorus Daily requirements range from read more .). Table 1 lists the current AIs for manganese. Li L, et al. Toxicological profile for manganese. However, it is not possible to determine to what extent, if any, the manganese alone affected bone density. Infants and children tend to absorb greater amounts of manganese than adults [7]. Accessibility which enables users to obtain detailed information and reports based on their genome. Adequate Intake (AI): Intake at this level is assumed to ensure nutritional adequacy; established when evidence is insufficient to develop an RDA. SelfDecode does not treat, diagnose or cure any conditions, 1. Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use. Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. The editorial team reserves the right to review and moderate the comments posted on the site. Abdelrahman MM, Alhidary IA, Aljumaah RS, Faye B. Manganese deficiency is very rare in humans, and signs and symptoms of deficiency have not been firmly established [1,2]. [3] A shortage of manganese in your body can impair normal growth, reduce fertility levels, affect insulin levels, and cause metabolism issues. More research is needed to determine whether manganese supplementation affects bone health in humans. The DV for manganese is 2.3 mg for adults and children age 4 years and older [17]. That said, most of what we know of dietary manganese deficiency comes from animal studies. HHS Vulnerability Disclosure, Help Postnatal vitamins are crucial to feeling your best after giving birth. Check out our post here. Soy-based infant formulas have higher manganese concentrations, 200 to 300 mcg/L, than milk-based formulas [12]. With manganese deficiency, there are no common causes. Sprinkle those suckers with some olive oil and seasoning and coat them evenly. In us, this enzyme is essential for immune function, and it uses primarily copper and iron. Medindia, viewed Jan 18, 2023, https://www.medindia.net/patients/lifestyleandwellness/manganese-deficiency.htm. There are a handful of cases of deficiency due to genetic causes. Manganese is a naturally occurring element and an essential mineral nutrient. This study also shows that zinc plays a role in modulation of Lyme . but is for informational and educational purposes alone. 2022 Oct 25. doi: 10.1007/s10534-022-00456-8. Due to its rarity, medical scientists havent firmly established what manganese deficiency looks like in the body. [. Phosphorus and calcium may also decrease your retention of manganese, but at a lower amount compared with iron. May Improve Bone Health in Combination With Other Nutrients Manganese is essential for bone health, including bone development and. We believe that the most accurate information is found directly in the scientific source. A deficiency in manganese can trigger diabetes. Supplements containing only manganese, or manganese with a few other nutrients, are also available, and most contain 5 to 20 mg manganese. Manganese deficiency and iron deficiency are both associated with fatigue, weakness, irritability and menstrual problems; however, an iron deficiency causes brittle or grooved nails while a manganese deficiency causes slow wound healing and bone problems. Aschner JL, Aschner M. Nutritional aspects of manganese homeostasis. For a reader-friendly overview of Manganese, see our consumer fact sheet on Manganese. Please confirm that you are a health care professional. A deficiency typically occurs only if manganese is eliminated from the diet. Zinc levels have been low in some patients, but normal in others [22]. So, how do you know whether youre getting enough of this essential micronutrient? Plus, you get to enjoy a manganese-rich breakfast without even chewing! SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Am J Clin Nutr 1999;70:37-43. Clin Chem Lab Med 2013;51:1555-61. [, Ekin S, Mert N, Gunduz H, Meral I. Serum sialic acid levels and selected mineral status in patients with type 2 diabetes mellitus. (2001). But when manganese levels fall out of whack, the trouble starts. This can be harmful because this is one of the . We suggest adding some toasted, chopped hazelnuts or pecans for a manganese boost (and added crunch and flavor to boot). While an uncommon disorder, manganese deficiency can have serious consequences, including . [2] Manganese works with vitamin K to assist in wound healing by clotting the blood. The U.S. Department of Agricultures FoodData Central website [11] lists the nutrient content of many foods and provides a comprehensive list of foods containing manganese ordered by nutrient content.

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